News from the
Institute for Cellular and Molecular Immunology

July 2017:

Surprising findings on the treatment of allergic asthma: a study from the group of Prof. Dr. Holger Reichardt reveals a new mechanism of glucocorticoids in the lung.

Publication: Klaßen, C., Karabinskaya, A., Dejager, L., Vettorazzi, S., Van Moorleghem, J., Lühder, F., Meijsing, S.H., Tuckermann, J.P., Bohnenberger, H., Libert, C., and Reichardt, H.M. (2017). Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma. Journal of Immunology 199, 48-61 (including cover page).

Background: The standard therapy of allergic asthma consists of the administration of synthetic glucocorticoids. Up to now, it was assumed that they primarily repress the function of immune cells. The recently published data, however, indicate that glucocorticoids directly act on the lung as well, in particular type 2 alveolar epithelial cells. This finding provides a new rational for the future development of improved therapies.

Further information is available on the [Homepage of The Journal of Immunology]


May 2015:

A report recently published in Nature by several research teams from the US and Germany, amongst others those of Prof. Dr. Peter Huppke and Prof. Dr. Holger Reichardt from the University of Göttingen Medical School, contradicts earlier findings suggesting that Rett Syndrome might be cured by bone marrow transplantation.

Publication: Wang, J., Wegener, J.E., Huang, T.-E., Sripathy, S., De Jesus-Cortes, H., Xu, P., Tran, S., Knobbe, W., Leko, V., Britt, J., Starwalt, R., McDaniel, L., Ward, C., Parra, D., Newcomb, B., Lao, U., Nourigat, C., Flowers, D.A., Cullen, S., Jorstad, N.L., Yang, Y., Glaskova, L., Vigneau, S., Kozlitina, J., Yetman, M.J., Jankowsky, J.L., Reichardt, S.D., Reichardt, H.M., Gärtner, J., Bartolomei, M.S., Fang, M., Loeb, K., Keene, C.D., Bernstein, I., Goodell, M., Brat, D.J., Huppke, P., Neul, J., Bedalov, A., Pieper, A.A. (2015). Wild type microglia do not arrest pathology in mouse models of Rett syndrome. Nature 521, E1-E4.

Background: Rett Syndrome is a genetic disease, which affects about 1 in every 10,000 girls. It is currently uncurable and causes severe neurological symptoms, and both intellectual and physical disabilities. A report published in 2012 provided promising evidence that bone marrow transplantation might be able to stop further progression of the disease. On the basis of these findings a clinical trial was initiated at the University of Minnesota. The new data, however, call the previous ones into question and indicate that the expected cure of the disease might not be possible.

Further information is available on the [Homepage of the journal Nature] as well as the [News service ScienceDaily]


February 2015:

Recommendation of a publication by the group of Prof. Dr. Holger Reichardt by the Faculty of 1000 as being of special significance in its field.

Publication: Reichardt, S.D., Weinhage, T., Rotte, A., Föller, M., Oppermann, M., Lühder, F., Tuckermann, J.P., Lang, F., van den Brandt, J., and Reichardt, H.M. (2014). Glucocorticoids induce gastroparesis in mice through depletion of L-arginine. Endocrinology 155, 3899-3908.

Background: Glucocorticoids are frequently used to treat inflammatory disorders. While it has been known for many years that such a treatment can be accompanied by side-effects such as osteoporosis and muscle atrophy, it now turned out that oral application also results in gastroparesis and potentially discomfort due to the empaired stomach emptying. However, this observation also explains for the first time the desired anti-emetic effect of glucocorticoids, which reduces nausea and vomitting during chemotherapy.

Further information is available on the [Homepage of the journal Endocrinology]


May 2014:

The group of Prof. Dr. Holger Reichardt has been granted the publication award Gö-VIP (Very Important Publication) by the Medical Faculty of the University of Göttingen for their recent work on the mechanism of glucocorticoids in the treatment of multiple sclerosis.

Publication: Schweingruber, N., Fischer, H.J., Fischer, L., van den Brandt, J., Karabinskaya, A., Labi, V., Villunger, A., Kretzschmar, B., Huppke, P., Simons, M., Tuckermann, J.P., Flügel, A., Lühder, F., and Reichardt, H.M. (2014). Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses. Acta Neuropathologica 127, 713-729.

Background: High-dose glucocorticoids have been used to treat acute disease bouts in multiple sclerosis patients for many years. In cooperation with the Institute for Multiple Sclerosis Research, the Department of Neurology and the Department of Pediatrics and Pediatric Neurology of the University of Göttingen Medical School it could now be shown for the first time that an altered migratory behavior of T lymphocytes considerably contributes to the efficacy of this therapy.

Further information is available on the [Homepage of the University of Göttingen Medical School]

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