Publikationen (AG Oppermann)
Originalarbeiten (nach der Habilitation)

1996

M. Oppermann, N. J. Freedman, R. W. Alexander, R. J. Lefkowitz. 1996. Phosphorylation of the type-1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J Biol Chem 271:13266   [Pubmed]

M. Oppermann, M. Diversé-Pierluissi, M. H. Drazner, S. L. Dyer, N. J. Freedman, K. C. Peppel, R. J. Lefkowitz. 1996. Monoclonal antibodies reveal receptor specificity among G protein-coupled receptor kinases. Proc Natl Acad Sci USA 93:7649  [Pubmed]

U. Höpken, M. Mohr, A. Strüber, H. Montz, H. Burchardi, O. Götze, M. Oppermann. 1996. Inhibition of IL-6 synthesis in an nimal model of septic shock by anti-C5a monoclonal antibodies. Eur J Immunol 26:1103  [Pubmed]

J. Elsner, M. Oppermann, A. Kapp. 1996. Detection of C5a receptors on human eosinophils and inhibition of eosinophil effector functions by CD88 antibodies. Eur J Immunol  26:1560  [Pubmed]

T. Werfel, J. Zwirner, M. Oppermann, A. Sieber, G. Begemann, W. Drommer, A. Kapp, O. Götze. 1996. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin. J Immunol 157:1729  [Pubmed]

T. Werfel, M. Oppermann, J.H. Butterfield, G. Begemann, J. Elsner, O. Götze, J. Zwirner. 1996. The human mast cell line HMC-1 expresses C5a receptors and responds to C5a but not to C5a(desArg). Scand J Immunol 44:30  [Pubmed]

1997

T. Werfel, M. Oppermann, G. Begemann, O. Götze, J. Zwirner. 1997. C5a receptors are detectable on mast cells in normal human skin and in psoriatric plaques but neither in wheal and flare reactions nor in urticaria pigmentosa by immunohistochemistry. Arch Dermatol Res 289:83  [Pubmed]

N.J. Freedman, A.S. Ament, M. Oppermann, R.H. Stoffel, S.T. Exum, R.J. Lefkowitz. 1997. Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. J Biol Chem 272:17734 [Pubmed]

N. Ishizaka, R.W. Alexander, J.B. Laursen, H. Kai, T. Fukui, M. Oppermann, R.J. Lefkowitz, P.R. Lyons, K.K. Griendling. 1997. G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. J Biol Chem 272:32482  [Pubmed]

1998

K. Lhotta, R. Würzner, F. Kronenberg, M. Oppermann, P. König. 1998. Rapid activation of the complement system by cuprophane depends on complement component C4.  Kidney Int 53:1044  [Pubmed]

M. Mohr, U. Höpken, M. Oppermann, C. Mathes, K. Goldmann, S. Siever, O. Götze, H. Burchardi. 1998. Effects of anti-C5a monoclonal antibodies on oxygen utilization in a porcine model of severe sepsis. Eur J Clin Invest 28: 227  [Pubmed]

1999

M. Oppermann, M. Mack, A. Proudfoot, H. Olbrich. 1999. Differential effects of CC chemokines on CC chemokine receptor CCR5 phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl-terminus. J Biol Chem 274:8875  [Pubmed]

F. Neuschäfer-Rube, M. Oppermann, U. Möller, U. Boer, G. P. Püschel. 1999. Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E2 receptor hybrid. Mol Pharmacol  56:419  [Pubmed]

P. Langkabel, J. Zwirner, M. Oppermann. 1999. Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by G protein-coupled receptor kinases. Eur J Immunol 29: 3035  [Pubmed]

G. Schlaf, E. Rothermel, M. Oppermann, H.L. Schieferdecker, K. Jungermann, O. Götze. 1999. Molecular cloning of the rat complement factor I. Investigations on the expression of factor I in rat and human cells and tissues. Immunology 98: 464  [Pubmed]

S. Ram, S., F.G. Mackinnon, S. Gulati, D.P. McQuillen, U. Vogel, M. Frosch, C. Elkins, H.K. Guttormsen, L.M. Wetzler, M. Oppermann, M.K. Pangburn, P.A. Rice. 1999. The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitides Mol Immunol 36: 915  [Pubmed]

H. Olbrich, A. Proudfoot, M. Oppermann. 1999. Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) J Leukocyte Biol 65:281[Pubmed]

2000

A. Fayyazi, O. Scheel, T. Werfel, S. Schweyer, M. Oppermann, O. Götze , J. Zwirner. 2000. The C5a receptor is expressed in renal proximal tubular but not in pulmonary or hepatic epithelial cells. Immunology 99:38  [Pubmed]

K.C. Peppel, A. Jacobsen, X. Huang, J.P. Murray, M. Oppermann, N.J. Freedman. 2000. Overexpression of protein-coupled receptor kinase 2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. Circulation 102:793  [Pubmed]

K. Lhotta, P. König, G. Mayer, M. Oppermann. 2000. Glomerular cells do not express the C5a receptor in human glomerulonephritis. Nephrol Dial Transplant 15:1888  [Pubmed]

2001

S. Chakrabarti, M. Oppermann, A.R. Gintzler. 2001. Chronic morphine induces the concomitant phosphorylation and altered association of multiple signaling proteins: A novel mechanism for modulating cell signaling Proc Natl Acad Sci USA 98:4209  [Pubmed]

H. Herfarth, B. Pollok-Kopp, A. Press, M. Oppermann. 2001. Polymorphism of CC chemokine receptors CCR5 and CCR2 in Crohn’s disease. Immunol Lett 77:113  [Pubmed]

K. Kraft, H. Olbrich, I. Majoul, M. Mack, A.E.I. Proudfoot, M. Oppermann. 2001.Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 which regulate signaling and receptor internalization. J Biol Chem 276:34408  [Pubmed]

2002

F. Hüttenrauch, A. Nitzki, F. Lin, S. Höning, M. Oppermann. 2002. ß-Arrestin binding to chemokine receptor CCR5 requires multiple C-terminal receptor phosphorylation sites and a conserved Asp-Arg-Tyr sequence motif. J Biol Chem 277:30769  [Pubmed]

T. Mokros, A. Rehm, J. Droese, M. Oppermann, M. Lipp, U.E. Höpken. 2002. Surface expression of the human cytomegalovirus encoded chemokine receptor US28 is regulated by ligand-independent phosphorylation. J Biol Chem 277:45122  [Pubmed]

2003

B. Pollok-Kopp, K. Schwarze, V.K. Baradari, M. Oppermann. 2003. Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem 278:2190  [Pubmed]

2004

N. Signoret, T. Christophe, M. Oppermann, M. Marsh. 2004. pH-Independent endocytic cycling of the chemokine receptor CCR5. Traffic 5:529  [Pubmed]

V. Schebeck-Fürstenberg, L. Ständker, M. Oppermann, D.E. Müller-Wiefel, W. Hahn, W.F. Blum, T. Braulke, B. Kübler. 2004. IGF binding protein-3 fragments in plasma of a child with acute renal failure. Pediatr Nephrol 19:1418  [Pubmed]

2005

E. Ponimaskin, A. Dumuis, M. Heine, K. Glebov, D.W. Richter, M. Oppermann. 2005. Palmitoylation of the 5-hydroxytryptamine(4a) receptor regulates receptor phosphorylation, desensitization and ß-arrestin mediated endocytosis. Mol Pharmacol 67:1434  [Pubmed]

N. Signoret, L. Hewlett, S. Wavre, A. Pelchen-Matthews, M. Oppermann, M. Marsh. 2005. Agonist-induced endocytosis of CC chemokine receptor 5 (CCR5) is clathrin-dependent. Mol Biol Cell 16:902  [Pubmed]

B. Lagane, S. Ballet, T. Planchenault, E. Le Poul, K. Balabanian, C. Blanpain, Y. Percherancier, I. Staropoli, G. Vassart, M. Oppermann, M. Parmentier, F. Bachelerie. 2005. Different structural requirements for CCR5-mediated signaling and receptor endocytosis. Mol Pharmacol 67:1966  [Pubmed]

S. Hummel, D. Schmidt, B Kremeyer, B. Herrmann, M. Oppermann. 2005. Detection of the CCR5-D32 HIV resistance gene in Bronze Age skeletons. Genes Immunity 6:371  [Pubmed]

F. Hüttenrauch, B. Pollok-Kopp, M. Oppermann. 2005 G Protein-coupled receptor kinases promote phosphorylation and ß‑arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. J Biol Chem 280:37503  [Pubmed]

2006

M. Oppermann, T. Manuelian, E. Brandt, J. Hellwage, S. Meri, C. Skerka, O. Götze, P.F. Zipfel. 2006. The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein. Clin Exp Immunol 144:342  [Pubmed]

J. Rivera-Nieves, J. Ho, G. Bamias, N. Ivashkina, K. Ley, M. Oppermann, F. Cominelli. 2006. Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology 131:1518  [Pubmed]

R. Purwar, M. Wittmann, J. Zwirner, M. Oppermann, M. Kracht, O. Dittrich-Breiholz, R. Gutzmer, T. Werfel. Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. J Immunol 177:4444  [Pubmed]

R. Schindler, T. Ertl, W. Beck, J. Lepenies, O. Boenisch, M. Oppermann, E. Kaspar, U. Frei. 2006. Reduced cytokine induction and removal of complement products with synthetic hemodialysis membranes. Blood Purif 24:203  [Pubmed]

2007

B. Pollok-Kopp, F. Hüttenrauch, S. Redthorn, M. Oppermann. 2007. Dynamics of protein kinase C mediated phosphorylation of the C5a receptor on serine-334. J Biol Chem 282:4345-53  [Pubmed]

M. Józsi, S. Strobel, H.M. Dahse, W.S. Liu, P.F. Hoyer, M. Oppermann, C. Skerka, P.F. Zipfel. 2007. Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome. Blood. 110:1516  [Pubmed]

M. Józsi, M. Oppermann, J.D. Lambris, P.F. Zipfel. 2007. The C-terminus of complement factor H is essential for host cell protection. Mol Immunol 44:2697  [Pubmed]

2008

E.S. Suvorova, J.M. Gripentrog, M. Oppermann, H.M. Miettinen. 2008. Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor. Biochim Biophys Acta - Molecular Cell Research 1783:1261-70  [Pubmed]

H.P. Scholl, P. Charbel Issa, M. Walier, S. Janzer,B.  Pollok-Kopp, F. Börncke, L.G. Fritsche, N.V. Chong, R. Fimmers, T. Wienker, F.G. Holz, B.H. Weber, M. Oppermann. 2008. Systemic complement activation in age-related macular degeneration. PLoS One. 3(7):e2593  [Pubmed]

2009

X. Cai, J.H. Wu, S.T. Exum, M. Oppermann, R.T. Premont, S.K. Shenoy, N.J. Freedman. 2009. Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis. Mol Pharmacol. 75:626  [Pubmed]

S. Strobel, P.F. Hoyer, C.J. Mache, E. Sulyok, W.S. Liu, H. Richter, M. Oppermann, P.F. Zipfel, M. Józsi. 2009. Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome. Nephrol Dial Transplant[Pubmed]

2010

L.A. Hecker, A.O. Edwards, E. Ryu, N. Tosakulwong, K.H. Baratz, W.L. Brown, P. Charbel Issa, H.P. Scholl, B. Pollok-Kopp, K.E. Schmid-Kubista, K.R. Bailey, M. Oppermann. 2010. Genetic control of the alternative pathway of complement in humans and age-related macular degeneration. Hum Mol Genet 19:209 [Pubmed]

Fritsche LG, Lauer N, Hartmann A, Stippa S, Keilhauer CN, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Weber BH, Skerka C. 2010. An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet. 19:4694 [Pubmed]

2011

Aung T, Chapuy B, Vogel D, Wenzel D, Oppermann M, Lahmann M, Weinhage T, Menck K, Hupfeld T, Koch R, Trümper L, Wulf GG. 2011. Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci USA. 108:15336 [Pubmed]

2013

Oppermann M, Würzner R, Wienands J. 2013. Obituary Prof. Dr. med. Otto Götze 1935–2013. Eur J Immunol, 43: 3094–3095

2014

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM (2014). Glucocorticoids induce gastroparesis in mice through depletion of L-arginine. Endocrinology (DOI: 10.1210/en.2014-1246). [Pubmed]

Übersichtsartikel

H. Olbrich, A. Proudfoot, M. Oppermann. 1999. Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) J Leuk Biol 65:281  [Pubmed]

M. Oppermann. 2004. Chemokine receptor CCR5: Insights into structure, function and regulation. Cell Signal 16:1201  [Pubmed]

M. Józsi, T. Manuelian, S. Heinen, M. Oppermann, P.F. Zipfel. 2004. Attachment of the soluble complement regulator factor H to cell and tissue surfaces: Relevance for pathology. Histol Histopathol 19:251  [Pubmed]

Oppermann M, Würzner R. 2010. Modern determination of complement activation. Semin Thromb Hemost. 36:611 [Pubmed]

Oppermann M. 2010. Anti-infectives: current challenges and future perspectives. Curr Opin Pharmacol. 10:505 [Pubmed]

Buchbeiträge

M. Oppermann, R. Förster. Chemokines and Their Receptors: Biochemical, Structural and Biological Properties. 2005. In: Leukocyte Trafficking (eds A. Hamann, B. Engelhardt) Wiley Press, p 33-67

Patente

O. Götze, M. Schulze, M. Oppermann. 1999. Verfahren zum Nachweis und/oder der quantitativen Bestimmung von Komplementpeptid C5a und/oder C5adesarg. European Patent Office No. EP 90111920.6

M. Oppermann, A. Kannt, A. Pommerau, H. Thüring, J. Huber. 2003. High-throughput-assay with high sensitivity for measuring of the activity of ß-adrenergic receptor kinase and for determining of the impact of test substances on such activity. European Patent Office No. EP 030204429.1

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